Child Abuse - Global Clinical Trials Review, H1, 2015

. Buy Dorzolamide with free Rx DUBLIN--(BUSINESS WIRE)--Research and Markets (.researchandmarkets.com/research/gkqkt9/child_abuse) has announced the addition of the "Child Abuse Global Clinical Trials Review, H1, 2015" report to their offering. "Child Abuse Global Clinical Trials Review, H1, 2015" provides data on the Child Abuse clinical trial scenario. Buy Tadapox (Tadalafil with Dapoxetine) with no Rx Buy Niaspan (Niacin) without prescription This report provides elemental information and data relating to the clinical trials on Child Abuse. Buy Volumizing Shampoo online Buy Kamagra Soft (Sildenafil Citrate) with free Rx It includes an overview of the trial numbers and their recruitment status as per the site of trial conduction across the globe. http://webmdhelp.wordpress.com Buy Levlen (Ethinyl estradiol / Levonorgestrel) with free Rx The databook offers a preliminary coverage of disease clinical trials by their phase, trial status, prominence of the sponsors and also provides briefing pertaining to the number of trials for the key drugs for treating Child Abuse. Scope Data on the number of clinical trials conducted in North America, South and Central America, Europe, Middle-East and Africa and Asia-pacific and top five national contributions in each Clinical trial (complete and in progress) data by phase, trial status, subjects recruited and sponsor type Listings of discontinued trials (suspended, withdrawn and terminated) Clinical Trial Overview of Top Institutes / Government Centers for Disease Control and Prevention Duke University National Institute of Mental Health The Johns Hopkins University Yale University Allegheny-Singer Research Institute Boston Medical Center Georgia State University Goethe-Universitat Harborview Injury Prevention & Research Center For more information visit .researchandmarkets.com/research/gkqkt9/child_abuse

Global Hereditary Angioedema (HAE) Pipeline Insights Study 2015

. About Voveran (Diclofenac) DUBLIN--(BUSINESS WIRE)--Research and Markets (.researchandmarkets.com/research/p9sp4m/hereditary) has announced the addition of the "Hereditary Angioedema (HAE)-Pipeline Insights" report to their offering. Hereditary Angioedema (HAE) Pipeline Insights provides an in-depth analysis of the pipeline assets across Hereditary Angioedema (HAE). Buy Spices online About Imodium (Loperamide) with no prescription The main objective of this report is to track competitor pipeline molecules, related research activities, technology, collaborations, and in-licensing and out-licensing deals. http://asthmareview.wordpress.com About Norvasc (Amlodipine) with no Rx The Hereditary Angioedema (HAE) Report helps to identify emerging players with potentially strong product information and create effective counter-strategies to gain competitive advantage. Hereditary Angioedema (HAE) Pipeline Insights Report covers the Hereditary Angioedema (HAE) pipeline molecules at various stages of development, like pre-registration phase, clinical phases (Phase III, Phase II & Phase I), and pre-clinical and discovery phases. Buy Tadacip (Tadalafil) The Report also provides Hereditary Angioedema (HAE) related therapeutic assessments by molecule type, route of administration, monotherapy and combination products. About Desolett The Report also highlights the discontinued and inactive projects in the pipeline for Hereditary Angioedema (HAE). Scope - The report provides a Hereditary Angioedema (HAE) landscape across the globe - The report provides drug profiles which include product description, MOA, licensors & collaborators, technology, development partner and chemical information - Coverage of the Hereditary Angioedema (HAE) pipeline on the basis of target, MOA, route of administration, technology involved and molecule type - The report reviews key players involved in the therapeutics development for Hereditary Angioedema (HAE) and also provides company profiling - Pipeline products coverage based on various stages of development from NDA filings to discovery. - Provides pipeline assessment by monotherapy and combination therapy products, stage of development and molecule type For more information visit .researchandmarkets.com/research/p9sp4m/hereditary.

Cystic Fibrosis Foundation Announces Leadership Transition

BETHESDA, Md.--(BUSINESS WIRE)--The Cystic Fibrosis Foundation today announced that Robert J. About Dexone (Dexamethasone) with free Rx Beall, Ph.D., will step down as president and chief executive officer, effective December 31, 2015. Buy Rheumatrex (Methotrexate) He will be succeeded by Preston W. About Vibramycin (Doxycycline) with free prescription Campbell III, M.D., currently the Foundation’s executive vice president for medical affairs, a position he has held since 1998. During his 35 years with the Cystic Fibrosis Foundation – 21 years as its president and CEO – Beall has had a profound impact on the lives of people with CF. Buy Daivobet without prescription When he joined the Foundation, the median predicted age of survival for a person with the disease was 18 years of age – today it is more than 40 years. Buy Alfacip (Alfacalcidol) without prescription For the first time ever, more than 50 percent of people with CF are over 18 years of age. Buy Raspberry online CF is no longer a pediatric disease. “Since the Foundation was established, people with CF and their families have inspired us to reach milestones that once seemed unachievable,” said Beall. http://pharmaceutical-journal.blogspot.com “When I joined the Foundation in 1980, people with CF and their families had very little reason to hope for a better tomorrow. Now, we have two groundbreaking treatments that attack the underlying cause of the disease, an extensive nationwide network of CF care centers and a community of people with CF who are living longer, healthier lives than ever before.” Beall continued: “Despite these achievements, we know there is still so much work to be done. I am confident that Dr. Campbell, my trusted colleague, will guide the Foundation through our next era of groundbreaking research and care. I would like to thank my colleagues, partners and the families in the CF community for giving me the opportunity to lead this wonderful organization. It has been one of the great pleasures and privileges of my life.” Seamless Transition to New Leadership A CF trailblazer in his own right, Campbell has worked side by side with Beall for nearly two decades. In addition to overseeing the Foundation’s research and drug discovery and development efforts, Campbell directs its clinical trials program, network of care centers and national patient registry database. An accomplished pediatric pulmonologist, Campbell previously served as center director at the Vanderbilt University CF Care Center, where he expanded the program from 30 patients to more than 300 in just five years. Until recently, he continued to provide direct clinical care to patients at the Johns Hopkins CF Care Center. “It is an honor to follow the path laid out by Dr. Beall and to build upon his tremendous achievements,” said Campbell. “This is an exciting time for the Foundation. We are accelerating our mission to pursue daring new research, which we hope will one day lead to a lifetime cure, while we continue to expand services that help people with CF enjoy the best health and quality of life. As always, the needs of people with CF will guide everything that we do moving forward.” Beall and Campbell will work closely together to provide for a seamless transition of leadership and ensure the Foundation’s strong momentum continues. Innovative Approach to Research “Dr. Beall has set a new standard for entrepreneurship in leadership of a nonprofit medical research foundation,” said Francis S. Collins, M.D., Ph.D., director of the National Institutes of Health and co-discoverer of the cystic fibrosis gene. “His willingness to take major risks, while fully aware of the potential for failure, has led to the dramatic advances in the treatment of cystic fibrosis that the entire world now celebrates. While there is still much more to do before cystic fibrosis is vanquished, the momentum is unstoppable. Let us pause to give thanks to Bob – we got this far because he dared to dream.” Beall pioneered the Foundation’s successful venture philanthropy model, which has been a game changer in CF research and drug development. In 1997, he established the Foundation’s Therapeutics Development Program, a unique coalition that has advanced CF drug development through a centralized network of clinical trials and alliances with biotech companies. The program has been responsible for a continuum of breakthrough treatments, including Kalydeco™ and the recently approved Orkambi™, both of which attack the underlying cause of the disease. Unprecedented Accomplishments “We are profoundly grateful for Dr. Beall’s leadership and in awe of his many accomplishments. During his more than three decades with the Foundation, he has had a transformative impact on the CF community,” said Catherine C. McLoud, chair of the CF Foundation Board of Trustees. “It would be difficult to point to another nonprofit leader who has made such a dramatic difference in the lives of people with a disease, and nobody beats Dr. Beall’s record of innovation and passionate commitment to our mission.” About the Cystic Fibrosis Foundation The Cystic Fibrosis Foundation is the world s leader in the search for a cure for cystic fibrosis. The Foundation funds more cystic fibrosis research than any other organization, and nearly every CF drug available today was made possible because of Foundation support. Based in Bethesda, Md., the Foundation also supports and accredits a national care center network that has been recognized by the National Institutes of Health as a model of care for a chronic disease. The Cystic Fibrosis Foundation is a donor-supported nonprofit organization. For more information, go to .cff.org.

Two studies published in PLOS Pathogens this month shed further light on the effect of neutralizing antibodies in the steep challenge facing researchers to develop a vaccine against AIDS/HIV. About Dexone (Dexamethasone) with free Rx Nabs are immune proteins that can recognize, bind to, and trigger the elimination of a virus. Buy Rheumatrex (Methotrexate) Image credit: Dr. About Vibramycin (Doxycycline) with free prescription Alexandra Trkola The search for an effective vaccine for AIDS/HIV has long been a battle for scientists and researchers around the world. Buy Daivobet without prescription Although HIV incidence have remained stable around the world at 50,000 new infections per year, a cure still remains to be found. Neutralizing antibodies are immune proteins that can recognize, bind to, and trigger the elimination of a virus before it can establish a chronic infection. Buy Alfacip (Alfacalcidol) without prescription Nabs have previously been researched as a tool against HIV and AIDs. Buy Raspberry online In a study last year, scientists discovered for the first time how to create Nabs in those already infected with HIV-1. http://pharmaceutical-journal.blogspot.com Dr. Julia Overbaugh, from the Fred Hutchinson Cancer Research Center in Seattle, WA, and her team, focused on the role of Nabs in those "superinfected" with HIV, which is defined as those sequentially infected at least twice with HIV by different sexual partners. Results from 21 women who were tested suggest that Nabs mount a broad and potent response against diverse HIV subtypes. It is hoped that that this particular response can be mediated at least in part by polyclonal antibodies, which can then target different aspects of the virus. These findings follow on from the team s previous research into the superinfected. In that study, it was discovered that those infected twice had a more potent antibody response to the virus - which inhibited the virus from replicating - compared with women who have only been infected once. Dr. Overbaugh hopes further research can be done on those superinfected, stating further research may "provide insight to the development of a diverse Nab response with multiple epitope specificities." Direct cell to cell transmission more prone to mutation strains The second study published in PLOS Pathogens focused on Nabs effect on those infected with HIV/AIDS by cell-to-cell contact. Dr. Alexandra Trkola from the University of Zurich, Switzerland, and her colleagues, developed an assay that can specifically test the potency of Nabs to prevent direct cell-to-cell transmission of HIV. By establishing an assay system, the free virus infection is restricted, resulting in infections only occurring through cell-to-cell transmissions. Researchers were able to test whether a large selection of Nabs could prevent cell-to-cell transmission of different HIV strains. Although Nabs showed an overall decrease in activity, losses varied substantially depending on the antibody and virus strain examined. Scientists also discovered certain Nabs still retained activity during cell-to-cell transmission for individual viruses. However, this was generally not linked to a high potency of the free virus, but instead, displayed Nabs inhibiting prior to the binding of the virus to the CD4 receptor on T cells. Mathematical analysis showed that when the virus was transmitted via cell to cell transmission, it was substantially more prone to give rise to mutation strains that can escape immune control compared to free virus transmissions. Dr. Trkola said: "This highlights the importance of controlling virus replication via the cell-cell transmission pathway even if the contribution of this transmission should provide to occur to a less extent than free virus spread in infected individuals." Written by Peter Lam

Scientists 'hack' common gut bacterium

In a new study published in the journal Cell Systems, researchers reveal how they have engineered a common gut bacterium to have new functions, enabling control of gene expression in the intestinal tracts of mice. The researchers hope they can one day use intestinal signaling to modify gene expression via engineered bacteria, which could offer new treatment strategies for numerous health conditions. Study leaders Timothy K. Cozaar (Losartan) without Rx Lu and Christopher Voigt, of the Massachusetts Institute of Technology (MIT), and colleagues say their study could pave the way for the development of microbes that detect illness in the gut or that can deliver drugs. Researchers have been increasingly investigating how to engineer gut bacteria so it holds therapeutic potential. Sinequan (Doxepin) with no Rx Last year, for example, Medical News Today reported on a study by researchers from Vanderbilt University in Nashville, TN, which detailed how Escherichia coli bacteria were modified to reduce food intake and obesity in mice. The MIT team notes, however, that E. About Styplon () with no Rx coli is not present in the gut in abundance - it can be cleared within days of introduction. About Cyclosporine As such, they turned their attention to Bacteroides - specifically, a species called Bacteroides thetaiotaomicron. "Compared to E. Aricept (Donepezil) without prescription coli, Bacteroides populations exhibit low variation in abundance and long-term colonization," the authors explain. Buy Prenatal Vitamins online "B. http://futurepharmaceuticals.wordpress.com thetaiotaomicron is both prevalent (present in 46% of humans) and abundant [...] making it a promising organism for both understanding and manipulating the gut environment." In addition, the researchers say these bacteria are able to express genes "on demand" and engage in long-term interactions with human cells and other gut bacteria. This means a form of this bacteria engineered to deliver drugs and its expressed genes could remain in the gut for longer. Genes in engineered bacterium expressed based on what mouse is fed To engineer B. thetaiotaomicron, the MIT team combined a number of tools researchers have previously used to engineer other bacteria, including promoters, ribosome-binding sequences, memory switches and CRISPR interference, and introduced them to the bacterium. "We then showed that genetic devices could be implemented in the bacteria and be shown to function in the context of the mouse gut microbiome." says Lu. Explaining what these findings mean, Voigt says: "The culmination of the work is not only do you have an engineered bacterium that s colonized the mouse gut, but you can turn on which genes in the bacterium are active based on what you feed the mouse. That s really something new. It allows you to control what the bacterium is doing at the site of where it s operating." The researchers hope to move their work to human trials, but note there are some barriers to overcome first. For example, in this study, the mice had to be given antibiotics before their gut could be colonized with B. thetaiotaomicron. Also, the team says they need to demonstrate that the bacteria can be engineered to perform more complex functions, such as the ability to respond to a variety of sensory inputs. The researchers say the long-term goal is to use intestinal signaling to modify gene expression via engineered bacteria, which could offer new treatment strategies for a variety of health conditions. "The big picture is that the bacteria that live in us or on us impact human health in very significant ways and the existing techniques we have to modulate the microbiome - taking antibiotics or changing our diet - are relatively limited," notes Lu. "We re hoping that with these tools to precisely engineer the intimate interface between bacteria and humans we re going to be able to tackle some major health-related problems." Written by Honor Whiteman

Half of breast cancers 'could be slowed with a common hormone'

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Can playing Tetris reduce intrusive memories?

For individuals with post-traumatic stress disorder, unwanted visual memories are a common symptom. Aralen (Chloroquine Phosphate) with no prescription But a new study suggests that playing computer games 24 hours after a traumatic event may reduce the occurrence of such memories. Reactivating the emotional memories of participants prior to them playing a computer game reduced occurrence of related unwanted memories in the following week. It is estimated that around 7-8% of the US population will experience post-traumatic stress disorder (PTSD) at some point in their lives, with women more likely to develop the condition than men. PTSD is triggered by exposure to a traumatic event. Voltaren (Diclofenac Sodium) with free prescription Symptoms include feeling tense, sleep problems, feelings of guilt or depression and frightening thoughts. Buy Glycomet (Metformin) with free prescription One of the most common symptoms is repeated visual memories of the event that triggered the disorder. People with PTSD often remember moments of their terrifying ordeal in vivid detail and feel as if they are reliving the event over and over, which can severely impact day-to-day life. Psychotherapy is one of the primary treatments for PTSD. Buy Clotrimazole This may include cognitive restructuring, which involves helping people make sense of their bad memories in an attempt to help them cope. About Cialis Light Pack-90 () But according to the study researchers, strategies to prevent such memories are limited. "Currently, there are recommended treatments for PTSD once it has become established, that is, at least 1 month after the traumatic event, but we lack preventative treatments that can be given earlier," explains senior study author Emily Holmes, of the Medical Research Council Cognition and Brain Sciences Unit in the UK. Past studies have indicated that people who played the computer game Tetris within 4 hours of watching video footage of traumatic events were less likely to have fewer unwanted memories of those events. However, Holmes and colleagues note that it is unrealistic to expect people who are involved in a traumatic event to play a computer game in the 4 hours following. Buy Multi Oil Blends online But could doing so within 24 hours help reduce occurrence of unwanted memories? Combination of memory reactivation and Tetris reduced intrusive memories To test whether this might be the case, the researchers conducted two experiments that investigated the theory of memory reconsolidation - the idea that long-term memories can be recalled and modified. The idea was to reactivate old emotional memories of participants and see whether the reoccurrence of these memories could be reduced by computer game play. In the first experiment, the researchers induced intrusive memories in 52 participants by showing them a 12-minute film of traumatic events, such as a man drowning at sea or a young girl being hit by a car. Twenty-four hours after watching the film, half of the participants were shown stills from it as a way of reactivating their memories. http://mdreview.wordpress.com They then took part in a 10-minute filler task - allowing time for memory reconsolidation to begin - followed by 12 minutes of playing Tetris. The other half of the participants acted as controls, only taking part in the filler task before sitting quietly for 12 minutes. Over the next week, all participants were required to keep a diary of any intrusive memories that occurred - defined as "scenes of the film that appeared spontaneously and unbidden in their mind." The team s findings - published in the journal Psychological Science - revealed that the participants whose memories were reactivated before playing Tetris experienced fewer intrusive memories from the film than the control group. This finding was confirmed in the second experiment, in which four groups of participants performed the same tasks. In this experiment, however, the team also tested whether memory reactivation alone or Tetris alone could reduce occurrence of intrusive memories. They found it was only the use of memory reactivation and Tetris combined that led to fewer intrusive memories. Commenting on their results, study co-author Ella James, also of the Medical Research Council Cognition and Brain Sciences Unit, says: "Our findings suggest that, although people may wish to forget traumatic memories, they may benefit from bringing them back to mind, at least under certain conditions - those which render them less intrusive." Holmes notes that their research is in its early stages and further studies are required, but she says they hope to develop their approach, with the aim of creating a potential strategy to reduce intrusive memories for people with PTSD and other trauma-related conditions. "Better treatments are much needed in mental health," she adds. "We believe the time is ripe to use basic science about mechanisms - such as research on memory reconsolidation - to inform the development of improved and innovative psychological treatment techniques." In August 2014, Medical News Today reported on a study suggesting the way a person s memory is processed may influence their risk of developing PTSD. Published in the journal Clinical Psychological Science, the study suggests people who recall higher numbers of external details related to the traumatic event - such as editorial statements - may be at higher risk for PTSD. Written by Honor Whiteman

Independence Day fireworks 'cause significant rise in air pollution'

July 4th has been celebrated as the birth of American independence since 1776. Buy Avana (Avanafil) with free Rx Tonight, the sky will be illuminated with stunning fireworks displays that are taking place all over the US. About Amaryl (Glimepiride) But according to a new study, such festivities may have an unintended consequence - a significant increase in air pollution. Fireworks set off over the US on the evening of July 4th cause an average 42% rise in air pollution, according to the researchers. Published in the journal Atmospheric Environment, the study identifies a rise in fine particulate matter, or PM2.5 - particles that are 2.5 micrometers in diameter and smaller - on the evening of July 4th and the morning of July 5th. According to the US Environmental Protection Agency (EPA), these small particles are a health concern; they can easily pass through the throat and nose to the lungs, which can trigger shortness of breath, coughing, wheezing and asthma attacks, as well as long-term health effects - such as stroke and heart attack and death from lung and heart disease. It is well known that fireworks can present health risks. Astelin (Azelastine) with no Rx Last year, a Spotlight feature from Medical News Today noted that firework injuries - such as burns and other injuries to the hands, eyes and legs - increased by 30% compared with the previous year. According to the researchers of this latest study - including Dian J. About Ciloxan with free Rx Seidel of the National Oceanic and Atmospheric Association (NOAA) Air Resources Laboratory in College Park, MD - previous studies had identified increases in air pollutants during and following fireworks displays. "But no study to date has explored fireworks effects on air quality over large regions using systematic observations over multiple years to estimate typical regional PM [particulate matter] increases," they note. Concentrations of fine particulate matter 42% higher on evening of July 4th Seidel and study co-author Abigail N. Dilantin (Phenytoin) with no prescription Birnbaum, of the University of Maryland and student intern at NOAA, set out to address this research gap, assessing the air quality of 315 sites across the US on every 4th July between 1999 and 2013. "We chose the holiday, not to put a damper on celebrations of America s independence, but because it is the best way to do a nationwide study of the effects of fireworks on air quality," says Siedel. The researchers analyzed the hourly concentrations of fine particulate matter on the evening of July 4th, comparing them with those of the days before and after, The team found that on average, concentrations of fine particulate matter were 42% higher on the evening of July 4th, compared with the days before and after the holiday. Buy Liver Detox online Levels reached their highest between 9 pm and 10 pm, with increases beginning at 8 pm. http://anti-infectives-opinion.blogspot.com The increases lasted until around midday on July 5th. The researchers identified variations in PM2.5 concentrations between air quality monitoring sites, which appeared to be dependent on weather conditions and how close the fireworks were to the site. For example, concentrations were around 370% higher on the evening of July 4th at one site where the fireworks were set off in a field adjacent to it - which the team says is at a level well above the maximum 24-hour limit of 35 mcg per cubic meter set by the EPA. Commenting on the findings, Seidel says: "These results will help improve air quality predictions, which currently don t account for fireworks as a source of air pollution. The study is also another wake-up call for those who may be particularly sensitive to the effects of fine particulate matter." The team notes that while the EPA do not regulate fireworks, they do recommend that individuals who are sensitive to air pollution - such as those with asthma - watch fireworks displays from a distance and ensure they have any required medication to hand. Written by Honor Whiteman

'Artificial pancreas' holds promise for easier control of type 1 diabetes

. Buy L-Tryptophan online Isordil (Isosorbide dinitrate) with no Rx esearchers have created an implantable "artificial pancreas" that they say could eliminate the use of insulin injections and pumps for people with type 1 diabetes. People with type 1 diabetes have to endure multiple insulin injections daily or use an insulin pump to control their condition, but researchers say the artificial pancreas could offer a simpler management method. Francis J. http://cardiobloodreview.wordpress.com Buy Champix without prescription About Hard On Oral Jelly (Sildenafil Citrate) with free prescription Doyle and colleagues from the University of California-Santa Barbara reveal how the device can continuously measure an individual s blood glucose levels and automatically deliver insulin when required. They publish the details of their creation in the journal Industrial & Engineering Chemistry Research. According to the American Diabetes Association, around 1.25 million adults and children in the US have type 1 diabetes, of whom around 200,000 are under the age of 20. Type 1 diabetes is an autoimmune disease in which the pancreas stops producing the hormone insulin, which can result in dangerously high or low blood glucose levels. People with type 1 diabetes must measure their blood glucose levels by pricking their fingers for blood regularly throughout the day, using the measurements to calculate the insulin dose needed. To deliver insulin to the body, individuals must either inject themselves with the hormone multiple times throughout the day, or have a continuous infusion of the hormone via an insulin pump. But Doyle and colleagues say their new device could make managing type 1 diabetes much easier, abolishing the need for finger pricking and multiple injections. Optimum glucose levels maintained 78% of the time in computer tests In their study, the researchers detail the creation of a fully implantable artificial pancreas that uses an algorithm to monitor patients blood glucose levels and calculate the insulin dose needed, which is then automatically delivered to the body. On conducting computer testing of the device - involving simulation of a rise and fall in glucose levels that occurs after meals throughout the day - the team found it maintained the optimum blood glucose range of 80-140 mg/dL 78% of the time, "with no time spent in hypoglycemia." Speaking about the device at a press conference when it was first unveiled back in January, Doyle says he believes it has the potential to transform type 1 diabetes management, adding: "The closed-circuit system provides much tighter control at an unprecedented level to minimize complications and to improve the quality of life. It will have immediate benefits, as it will lower health care costs in the country and it will reduce the amount of decisions people with diabetes need to make on a constant basis." The researchers say they hope the artificial pancreas will be available for type 1 diabetes patients in the next 5 years, though the next step for the team is to conduct animal testing to "evaluate the in vivo performance" of the device. This is not the first artificial pancreas to be developed for type 1 diabetes. Buy Effexor Xr (Venlafaxine) with no prescription Buy Atripla (Efavirenz+Emtricitabine+Tenofovir) with no prescription In November 2014, Medical News Today reported how a team of Canadian researchers showed how two versions of an external artificial pancreas were more effective than an insulin pump for managing the condition. Written by Honor Whiteman